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GLP-1 medications slow gastric emptying and alter gut motility, which may indirectly affect stool characteristics through changes in transit time and dietary intake

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Despite these well-known risks, some data suggest roughly a third of individuals may not be fully adherent to pregnancy prevention guidelines (eg, intercourse with fewer than two forms of contraception, failure to remain abstinent, missing doses of oral contraceptives or in some cases, having completely unprotected intercourse). Because of these concerns, dermatologists may consider advocating for more reliable forms of contraceptives, including reversible contraceptives and intrauterine devices or implants, Blalock said

Intranasal administration through the olfactory pathway could enable researchers to investigate retatrutide effects on brain GLP-1, GIP, and glucagon receptors without the confounding variable of high peripheral peptide levels

PEGylation, which is often used to prolong circulation by reducing immune recognition, can induce anti-PEG antibodies [144]